New industrial connectivity architectures are driving three key Industry 4.0 use cases. While conducting research for the recently released Industry 4.0 and Smart Manufacturing Market Report, IoT Analytics identified new industrial connectivity architectures driving key Industry 4.0 use cases. In this article Matthew Wopata, a senior analyst at IoT Analytics, sheds some light on this emerging topic. Forward-thinking manufacturers and OEMs are using new technologies to realize key Industry 4.0 use cases that improve operational efficiencies and provide differentiated products and services. Many of these use cases require new and innovative connectivity architectures that challenge the existing status quo of the five-layer automation pyramid. This article explores four new industrial connectivity architectures and highlights three Industry 4.0 use cases that utilise these architectures to improve operational efficiencies and/or provide differentiated products and services.